AutoHotkey is a nifty scripting tool that can be used to automate almost any thing you can do with Windows. It’s extremely customizable: AutoHotkey scripts range from simple keyboard shortcuts to full-blown programs.
For example, my script file allows me to hit Windows Key+I to open my Inbox folder, where I have programs set to download/save files. I can also hit Windows Key+~ to bring up a Quake-style command prompt on the top of the screen, and I can hit Windows Key + Print Screen to save a time-stamped screenshot to my Inbox folder.
Or I can take it even further: If I hit Windows Key + Shift + Print Screen, AutoHotkey will A) take a screenshot, B) make a thumbnail of the screenshot, C) upload both to my web server, and D) place the HTML code to display the screenshot thumbnail, with a link to the full-sized image, onto my clipboard. (I’ve posted instructions on how to do all of the above.)
I’ve only barely scratched the surface of what AutoHotkey can do; the folks at Lifehacker have done a lot more with this awesome tool.