Leading the Parade of Aweome twhirl, the best ever desktop client for Twitter!
Twhirl has a clean and elegant interface, with your choice of several different color schemes. It handles replies and direct messages in the same box as the regular Twitter feeds, but highlights them so that they stand out. It’s fast, and it runs on Mac, OSX, and Windows because it uses Adobe AIR.
Fast, pretty, and usable: No wonder it leads the Parade of Awesome.